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Simple Truths About Muscle Growth (part 2) | Creatine Blog
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Simple Truths About Muscle Growth (part 2)


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In previous posts I have stressed the importance of the IGF-1s (Insulin-like growth factors, type 1) in promoting body growth. To reiterate the main message of my last (post): the IGF-1s are likely to be our most important growth promoters, particularly with reference to all types of muscle, bone and connective tissues. Importantly, these are the tissues an athlete must fortify in order to continue making gains.

Not too long ago, however, it was believed (wrongly) that the only way to produce IGF-1 was in response to another hormone called Growth Hormone; it is by no coincidence that “growth” is explicitly stated in this important hormone’s name. This story has recently been revised, which has very important implications for how an athlete trains, rests and eats...

Go here for more information about the IGF-1s: http://www.creatinemonohydrate.net/creatine_newsletter_33.html

There are Two Pathways that Produce IGF-1:

Pathway 1 (traditionally recognized): Growth Hormone Stimulates IGF-1 Production for Systemic Distribution

Particularly, while we sleep, IGF-1 is produced from the liver in response to Growth Hormone (GH) that in turn, is released from a gland at the base of the brain called the anterior pituitary. Thus, the old dogma states that GH (released from the brain) stimulates the liver to produce IGF-1 distally, that then enters the blood stream to stimulate muscle and bone growth systemically; that is, delivered via the blood derived fluids that baths all our muscles and bones. This was known as the GH axis.

Importantly, the GH-mediated rise in IGF-1 is most pronounced while we sleep, declines in advanced age and is attenuated by heavy alcohol consumption, helping to explain the anabolic effects of rest and alcohol moderation…

See this link for more information about Growth Hormone: http://www.creatinemonohydrate.net/growth_hormone.html

Pathway 2: Muscle Makes its Own IGF-1 for Local Use

We’ll it turns out that muscle does not (more precisely, cannot) simply wait for the brain “to decide” when it needs IGF-1. Muscle has thus evolved a way of producing its own supply of IGF-1 on demand, when challenged by a physical stress. That is, exercise. Exercise is one of the most potent stimulators of local IGF-1 production by muscle.  Nonetheless, the IGF-1 produced by muscle can also reach neighboring tissues such as bone, to assist in their development as well.

Exercise-induced IGF-1 production makes practical sense and “feels right” for must of us as our practical experience has shown us that exercise causes muscle growth and increases our strength. Even more, not exercising causes our muscles to shrink, or atrophy. Why do you think?

A Trick to Optimize Muscular IGF-1 Production

An unexpected nutritional intervention has been recently shown to augment the expression of IGF-1 in isolated muscle cells grown outside the animal, independently of exercise. That is, though muscle cells in a plastic dish can’t undertake training, they respond to this nutritional intervention just the same.  Obviously, this has important implications for the athlete or clinician trying to promote muscle or bone development. How to put this into play in “real” terms will be the topic of subsequent posts.

If you are in a hurry for the answer click here: http://www.creatinemonohydrate.net/creatine guide

This entry was posted in Muscle Growth, Supplementing Strategies and tagged , , , , , , , , , . Bookmark the permalink. Post a comment or leave a trackback: Trackback URL.

18 Comments


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    . When produced locally, IGF-1 is often modified to form a slightly different protein called mechano-growth factor or MGF. Testosterone stimulation of the androgen receptor has been shown to result in local production of IGF-1 in skeletal muscle.


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    I drop a leave a response whenever I like a article on a site or
    I have something to contribute to the conversation. It’s triggered by the passion displayed in the article I browsed. And on this article Simple Truths About Muscle Growth (part 2) | Creatine Blog. I was actually moved enough to post a comment ;) I actually do have a couple of questions for you if it’s allright.
    Could it be simply me or do a few of the comments look like they are written by brain dead individuals?
    :-P And, if you are posting on additional online social sites, I would like to follow everything fresh you have to post.
    Would you list all of your community sites like your Facebook page, twitter
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    . When produced locally, IGF-1 is often modified to form a slightly different protein called mechano-growth factor or MGF. Testosterone stimulation of the androgen receptor has been shown to result in local production of IGF-1 in skeletal muscle.


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    Robin
    Posted May 11, 2013 at 5:32 am | Permalink

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    Hey There. I found your blog using msn. This is a really well written article.
    I’ll make sure to bookmark it and come back to read more of your useful information. Thanks for the post. I’ll definitely comeback.


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    In normal ranges, IGF-1 in the body aids growth and boosts muscle strength, he said. The hormone also increases metabolism of carbohydrates, bringing more sugars to the cells that also help muscle growth.


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    Having read this I thought it was very enlightening.

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    But so what, it was still worth it!


  18. Strict Standards: call_user_func_array() expects parameter 1 to be a valid callback, non-static method GA_Filter::comment_author_link() should not be called statically in /home/creati40/public_html/creatine-blog.com/wp-includes/plugin.php on line 166

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