Hello Rob,
Nicely formulated question, but you got me right where it hurts, the lack of published scientific studies addressing creatine’s solubility and degradation in aqueous solutions. Below is what I have been able to piece together from the literature that I have been able to find. Other reports surely exists, I have simply not been able to pin them down.
Since one of your queries uses the term, thermodynamics, I use this approach to answer the question. Don’t worry. I’ll try and develop the answer in an intuitive manner, not like a university physical chemistry course.
Ok, buckle-up, here we go…
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Dear Readers,
A version of this question appeared in my inbox a few days ago. I felt it important enough to merit its own post in this blog. Today, I’ll post the original question and in a few days I’ll upload my answer.
Sincerely,
Alfredo Franco-Obregón
Nutritional Supplements Newsletters Publishing
Question
Following is a question regarding “Creatine Solubility” that I haven’t seen addressed within the contents of your website and the answer to which could prove to be of great value and interest not only to myself but to all your readers & visitors to this website. I have yet to receive a fair & comprehensive answer to my question from any other sources which is why I’m now turning to you for help.
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Life without calcium would not be possible. Calcium is an indispensable regulator of many essential biochemical processes. The cellular behaviors regulated by calcium range from the reading of genes to produce cellular components to the activating of all forms of cellular movement, including muscle contraction. In fact, creatine makes muscle contraction more efficient by increasing the availability of calcium.
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Although nowhere nearly as robustly (or obviously) as muscles, bones also develop in response to exercise. Because this effect is largely hidden from view, however, most athletes are not aware of its importance to athletic performance. In truth, bones must increase in strength in parallel to muscle mass in order to support the higher levels of mechanical stress being placed upon them by stronger, larger muscles. As we will learn today both these processes are reliant on creatine…
In my last post (see Creatine builds strong bones… part 1) I made the case that creatine supplementation, by way of maximizing muscular force generation, promotes bone formation (osteogenesis). Although muscular activity surely contributes to the bone formation observed with creatine, this cannot be the entire story. Situations have been described where creatine treatment promotes osteogenesis outside the animal. That is, creatine supplementation, in the absence of mechanical stimulation imposed by skeletal muscle, also appears to promote bone formation.
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Posted in Elderly | Tagged bone, cartilage, chondrocytes, creatine monohydrate, Elderly, exercise, mechanical stimulation, muscle, osteoblast, osteoclasts, osteogenesis |
Most athletes are trying to take greater advantage of the fact that muscle develops in response to physical exercise. One important way to optimize the anabolics of exercise is through the application of smart nutritional strategies, the reason, I suppose, that many of you are reading this blog today.
We Are The Product of Mechano-sensitive Developmental Programs
Muscle, however, is not the only tissue of our body that develops in response to physical (aka “mechanical”) stimulation. In fact, over 80% of our entire body mass arises from tissues whose developmental programs are regulated be mechanical stimulation. Such “mechanosensitive” tissues include not only skeletal muscle, the most obvious example, but also tendons, cartilage (as that which cushions the contacts between bones in our joints) and bones, to name the most notable. Of these common examples, skeletal muscle is the most predominant in mere proportion of total body mass as well as the most sensitive to mechanical input.
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Posted in Elderly | Tagged bone, catabolism, creatine, creatine monohydrate, development, Elderly, mechanosensitive, muscle, osteogenesis, osteoporosis, sarcopenia |
