Deprecated: Assigning the return value of new by reference is deprecated in /home/creati40/public_html/ on line 520

Deprecated: Assigning the return value of new by reference is deprecated in /home/creati40/public_html/ on line 535

Deprecated: Assigning the return value of new by reference is deprecated in /home/creati40/public_html/ on line 542

Deprecated: Assigning the return value of new by reference is deprecated in /home/creati40/public_html/ on line 578
Creatine builds strong bones… part 2 | Creatine Blog

Creatine builds strong bones… part 2

Although nowhere nearly as robustly (or obviously) as muscles, bones also develop in response to exercise. Because this effect is largely hidden from view, however, most athletes are not aware of its importance to athletic performance. In truth, bones must increase in strength in parallel to muscle mass in order to support the higher levels of mechanical stress being placed upon them by stronger, larger muscles. As we will learn today both these processes are reliant on creatine…

In my last post (see Creatine builds strong bones… part 1) I made the case that creatine supplementation, by way of maximizing muscular force generation, promotes bone formation (osteogenesis). Although muscular activity surely contributes to the bone formation observed with creatine, this cannot be the entire story. Situations have been described where creatine treatment promotes osteogenesis outside the animal. That is, creatine supplementation, in the absence of mechanical stimulation imposed by skeletal muscle, also appears to promote bone formation.

Osteogenesis: Delicate Balance Between Bone Loss and Gain
Osteogenesis is an ongoing battle between two types of bone progenitor cells, osteoclasts that destroy existing bone and osteoblasts that lay down new bone matrix. Mechanical stimulation activates osteoblasts, whereas it inhibits the destructive behavior of osteoclasts. Via the selective activation of osteoblasts exercise stimulates bone development.

Creatine Supports Bone and Cartilage Development
Areas of active bone and cartilage growth have been shown to possess high levels of phosphocreatine (the biologically active form of creatine). The incidence of creatine transporters (that deliver creatine to the inside of cells) is also elevated in areas of bone and cartilage growth. These two findings provide strong evidence for the importance of creatine to the developmental programs of bone and shock-absorbing cartilage. The study we discuss today demonstrates just how sensitive one is to the presence of creatine.

The Study:
“Stimulatory effects if creatine on metabolic activity, differentiation and mineralization of primary osteoblast-like cells in monolayer and micromass cell cultures.” Gerber et al., (2005) European Cells and Materials Volume 10, pages 8-22.
This study was conducted under auspices of a respected colleague at the Swiss Federal Institute of Technology, the ETH. The investigator’s name is Dr. Theo Wallimann one of the leading experts on creatine transport mechanisms.

Dr. Walliman and colleagues conducted their analysis on osteoblastic progenitor cells in tissue culture and hence, outside the animal. Briefly, osteoblasts were isolated from the bones of rats and transferred into sterile containers where they were allowed to organize themselves into either three-dimensional or two-dimensional systems of cells; the three-dimensional configuration is a closer approximation to the natural state. That is, bones are more like solid posts, than flat sheets. The advantage of conducting studies in tissue culture is the cells reside in a minimized environment that is completely under the control of the experimenter and not influenced by other tissue types, or hormones released by the animal into the blood stream. In essence, the scientist can then be assured that they are only examining the effects of creatine on bone development - osteogenesis.

The authors of the study found that creatine treatment significantly improved the ability of osteoblasts to produce nascent bone matrix. Moreover, the “osteogenic” effect of creatine was greater in the three-dimension cultures, providing even greater physiological relevance to the effect of creatine.

Interestingly, lower doses (10 mM; 1.3 grams per liter of cell medium) of creatine appeared to be more effective, than larger doses (20 mM; 2.6 grams per liter of cell medium) at permitting osteoblasts to multiply in number. Larger doses of creatine monohydrate, while still promoting the excretion of bone matrix, reduced the number of surviving cells. That is, although both concentrations of creatine promoted bone development, the larger dose seemed to slow cell growth. This is not the first study to demonstrate an adverse of effect of high doses of creatine monohydrate on cells grown outside the animal. Another study also demonstrated that larger doses of creatine (greater than 0.1%; 1 gram per liter of cell medium) also slowed the growth of muscle cells when maintained in tissue culture. This second study will be discussed at a later date in this blog. Nevertheless, the reason for this growth retarding effect of higher doses of creatine is still unclear. Therefore, at least in tissue culture, high doses of creatine monohydrate appear to exert a negative effect, whereas more moderate doses exert a clear benefit on cell duplication.

This creatine guide gives a dosing protocol to be used with moderate doses of creatine:

Remaining to be Shown
More studies need to be conducted in intact animals to corroborate this preliminary, yet provocative, finding – that creatine directly enhances the osteogenic potential of osteoblasts. Studies examining the effect of creatine on cartilage formation from progenitors cells (chondrocytes) also needs to be undertaken.

Take home
In brief, creatine supports development of muscle, bone as well as cartilage. On the one level, creatine increases force production by muscle, which serves as an anabolic stimulus for bones and cartilage. On the other level, creatine appears to directly stimulate the production of muscle, bones and most likely cartilage – independently of mechanical stimulation. The combination of creatine and exercise will thus have an even more potent effect on the developmental programs of these important support tissues.

Although for a young person it is hard to image what a loss of these tissues means to one’s quality of life, most elderly endure reduced mobility daily. Creatine supplementation would thus help improve the quality of life of the elderly by helping maintain more youthful levels of muscle, bone and cartilage.

Learn about other benefits of creatine supplementation for the elderly at the following links:

Stay tuned to part three of this series of posts discussing the positive effects of creatine supplementation over bone development.

This entry was posted in Elderly and tagged , , , , , , , , , , . Bookmark the permalink. Post a comment or leave a trackback: Trackback URL.


  1. Posted March 2, 2009 at 10:20 pm | Permalink

    Creatine has been a well regarded supplement for nearly twenty years and for good reason: It works. Creatine is probably the most researched supplement on the market when it comes to increasing strength and muscle size

  2. Posted June 3, 2011 at 6:39 am | Permalink

    Thank you for some other excellent article. The place else may just anybody get that kind of info in such a perfect manner of writing? I have a presentation next week, and I’m at the search for such info.

  3. Posted July 4, 2011 at 5:00 am | Permalink

    Ever since i heard about about this Creatine. I wonder how it really works then a teacher explains me some important details about it. After that they i search for it and found out hoe Creatine really works. Its definitely great supplement. I know some gym addicts use this supplement for sure.

  4. Posted October 14, 2011 at 4:43 am | Permalink

    Somebody essentially help to make seriously posts I would state. This is the first time I frequented your website page and thus far? I amazed with the research you made to make this particular publish extraordinary. Wonderful job!

  5. Birdie Lauthern
    Posted April 23, 2013 at 4:31 pm | Permalink

    I just want to tell you that I am beginner to blogs and absolutely loved you’re website. More than likely I’m planning to bookmark your site . You really have superb writings. Thanks a lot for sharing your webpage.

  6. http://Www.
    Posted April 24, 2013 at 8:41 am | Permalink

    Hello There. I found your blog using msn. This is
    a really well written article. I will make sure
    to bookmark it and come back to read more of your useful information.
    Thanks for the post. I’ll definitely comeback.

  7. Posted April 26, 2013 at 8:48 am | Permalink

    I’m now not sure where you’re getting your information, however good topic. I must spend a while finding out more or understanding more. Thanks for great info I used to be searching for this info for my mission.

  8. Posted April 26, 2013 at 12:31 pm | Permalink

    Have you ever considered creating an e-book or guest authoring on other blogs? I have a blog based upon on the same information you discuss and would really like to have you share some stories/information. I know my viewers would enjoy your work. If you are even remotely interested, feel free to shoot me an e mail.

  9. Posted April 26, 2013 at 11:39 pm | Permalink

    I’m now not certain the place you’re getting your info, however good
    topic. I must spend a while studying more or figuring out more.
    Thanks for excellent info I used to be searching for this information for
    my mission.

  10. Creatine Blog
    Posted April 27, 2013 at 3:23 am | Permalink

    You are very welcome to share my information with your readers, just please post a visible link back to this site. Thanks for the comments and collaboration. Much appreciated

  11. Posted April 30, 2013 at 8:50 pm | Permalink

    Excellent distribute it will likely be seriously. Were waiting for with this information.

  12. Posted May 2, 2013 at 5:16 am | Permalink

    I am curious to find out what blog system you’re using? I’m experiencing some small security problems with my latest blog and I’d like to find something more safeguarded. Do you have any recommendations?

  13. Posted May 3, 2013 at 1:45 pm | Permalink

    You made a number of reputable details presently there. My partner and i looked on the web for the issues determined most individuals will certainly keep company with with your website.

  14. Posted May 5, 2013 at 10:36 am | Permalink

    Hi! Quick question that’s completely away subject matter. Did you know learning to make your website cellular helpful? My personal weblog seems unusual any time searching through my own iphone4. I am just hunting for a theme or wordpress tool that has to be in a position to solve this problem. For those who have any ideas, you should talk about. Regards!

  15. Posted May 7, 2013 at 2:05 am | Permalink

    It’s about time likely to be several dull older distribute, however it critically paid for with regard to my time. I’ll post one of the links to this page on my own weblog. I am positive this site site visitors will come across that truly useful.

  16. Posted May 8, 2013 at 1:05 am | Permalink

    Nice post. I was checking continuously this blog and I am impressed!
    Very useful info specially the last part :) I care for such
    information a lot. I was looking for this certain information for a long time.
    Thank you and best of luck.

  17. Posted May 9, 2013 at 7:45 am | Permalink

    Very interesting matter , thanks for putting up.

  18. Posted May 10, 2013 at 4:57 pm | Permalink

    Pretty section of content. I just stumbled upon your
    blog and in accession capital to assert that I get actually
    loved account your weblog posts. Any way I’ll be subscribing on your feeds and even I achievement you access persistently fast.

  19. Posted May 12, 2013 at 2:07 am | Permalink

    Hi thеre to eνeгу single onе,
    іt’s genuinely a nice for me to go to see this web page, it includes helpful Information.

    Look at my site; tao of badass review

  20. Posted May 12, 2013 at 10:47 pm | Permalink

    We’ve actually loved reading your site content. A person obviously understand what you are referring to! Your site is so easy to be able to find their way also, We’ve saved the idea within my favourites features and functions.While looking yahoo and google I discovered this page. Your article is really what We are trying to find. Entire article is developed in really helpful means. Anticipating for additional articles.

  21. Posted May 19, 2015 at 12:47 am | Permalink

    Thanks for finally writing about > Creatine builds strong bones… part 2
    | Creatine Blog < Liked it!

One Trackback

  1. By payday loans uk on May 8, 2013 at 1:20 pm

    payday loans uk…

    I’ve several question to you, write to these I do not e-mail…

Post a Comment

Your email is never published nor shared. Required fields are marked *


You may use these HTML tags and attributes: <a href="" title=""> <abbr title=""> <acronym title=""> <b> <blockquote cite=""> <cite> <code> <del datetime=""> <em> <i> <q cite=""> <strike> <strong>